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Leflunomide medac is an drug used to treat adult patients with active rheumatoid arthritis or with active psoriasisartrit.
Contact your doctor immediately and stop taking Leflunomide medac:
if you feel weak, dizzy or have difficulty breathing, as these may be symptoms of a serious allergic reaction.
if you get a skin rash or ulcers in your mouth, as these may indicate severe, sometimes life-threatening reactions (eg. ex. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms [DRESS]), see section 2.
Contact your doctor immediately if you experience:
paleness, tiredness, or bruising, as these may indicate blood disorders caused by an imbalance between the different types of blood cells in the blood.
fatigue, abdominal pain or jaundice (yellowing of the eyes or skin), as these may indicate serious conditions such as liver problems that could be life-threatening.
symptoms of infection such as fever, sore throat or cough, as this medicine may increase the risk of serious infections that can be life threatening.
cough or breathing problems as these may indicate problems in the lungs (interstitial lung disease or pulmonary hypertension).
unusual tingling, weakness or pain in your hands or feet as these may indicate problems with your nerves (peripheral neuropathy).
Common side effects (may affect up 10 %)
a slight decrease in the number of white blood cells (leukopenia),
mild allergic reactions,
loss of appetite, weight loss (usually insignificant)
abnormal skin sensations like tingling (paraesthesia),
mild increase in blood pressure,
colitis (intestinal inflammation)
inflammation of the mouth or mouth ulcers,
elevation of certain liver enzymes;
eczema, dry skin, rashes and itching,
tendonitis (pain caused by inflammation of the membrane surrounding the tendons usually in the feet or hands),
an increase of certain enzymes in the blood (creatine phosphokinase),
peripheral nerves of the arms and legs (peripheral neuropathy).
Uncommon side effects (may affect up to 1%)
a decrease in red blood cells (anemia) and a decrease in the number of platelets
a lowering of blood potassium levels,
an increase in fat levels in the blood (cholesterol and triglycerides),
a reduction of phosphate in the blood.
Other side effects such as kidney failure, a decrease of uric acid in the blood, pulmonary hypertension, male infertility (which is reversible once treatment with this medicine is stopped), cutaneous lupus (characterized by rash/ redness on skin areas exposed to light), psoriasis (new or aggravated) and DRESS may also occur with an unknown frequency.
If you didn't have psoriasis before,
Other side effects: psoriasis (new or aggravated)
Leflunomide medac might give it to you.
Special warnings and precautions for use
Very rare cases of Stevens-Johnson syndrome or toxic epidermal necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) have been reported in patients treated with leflunomide.
Leflunomide medac can cause Stevens-Johnson syndrome
To find the words Stevens-Johnson syndrome in the text, Press CTRL + F (on a Windows PC) and write Stevens-Johnson syndrome then press enter.
"Stevens-Johnson syndrome, also called SJS, is a rare but serious problem. Most often, it's a severe reaction to a medicine you've taken. It causes your skin to blister and peel off. It affects your mucus membranes, too. Blisters also form inside your body, making it hard to eat, swallow, even pee."
Warning, the following link shows images of Stevens-Johnson syndrome, a horrific disease when skin peels of the body.
Stevens-Johnson syndrome images